Aceclofenac is a non steroidal anti-inflamatory drug, active against arthritis to relive pain and inflammation. The main objective of this research work was to prepare ethyl cellulose microspheres loaded with aceclofenac and in-vitro drug release study. In the present study, emulsion solvent evaporation method is used for preparing microspheres. The polymer (EC) and drug (aceclofenac) was dissolved in acetone. Surfactant was added to this solution and stirred it for 30 min. The oil and 1 drop of span‐80, span-20, tween 80, tween 20 (as emulsifier) were mixed together and allowed to stir for 2 hrs at 800‐1000 rpm. The aqueous phase was added to oil phase to form primary emulsion. This emulsion was stirred for 3 hrs at 800‐1000 rpm. Microspheres were filtered and dried in dessicator over night. Microspheres were spherical shape and smooth surface. Infra‐red spectra showed identical peaks of drug and polymer drug entrapment efficiency was 92% determined by UV‐ spectrophotometer at 274 nm. In-vitro drug release studies were performed using USPII Dissolution Apparatus. The formulation EC Showed 88.5% drug was released in 10 hrs. It is concluded that EC microspheres of aceclofenac can be prepared by emulsification solvent evaporation method and in-vitro release data is satisfactory with an aim to develop sustained release matrix tablets (SRMTs) of aceclofenac, which prolongs the release of drug that is released/ dissolved and also aimed to reduce gastric irritation by preparing microspheres of aceclofenac. And then the tablets are prepared by direct compression method to increase the sustained activity and to reduce the dosing frequency. The formulation showed 92.25% drug was released in 24 hrs. The prepared tablets were evaluated for pre and post compression parameters, drug content, in-vitro dissolution studies and stability studies.
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